IHC-66可对抗乌头碱及BaCl_2所致麻醉大鼠的心律失常,显著降低氯仿诱发小鼠室颤发生率,减低ClCl_2引起小鼠室颤发生率和死亡率,对抗CaCl_2-Ach诱发小鼠房颤发生率。增加哇巴因诱发豚鼠室早、室颤和心脏停搏用体,可缩短氯仿-肾上腺素所致家兔心律失常的时间。其作用机理可能是与非特异性的干扰了细胞膜对Na~+、K~+和Ca~(2+)的跨膜转运有关。 IHC-66 can counter arrhythmia induced by aconitine and BaCl 2 in anesthetized rats, significantly reduce the incidence of ventricular fibrillation in mice induced by chloroform, and reduce the incidence and mortality of ventricular fibrillation induced by ClCl 2 in mice, against CaCl 2 -Ach-induced mice. The incidence of atrial fibrillation. Increasing the amount of ouabain-induced ventricular premature beats, ventricular fibrillation, and cardiac arrest in guinea pigs can shorten the time of arrhythmia induced by chloroform-adrenaline in rabbits. The mechanism may be related to non-specific interference with the transmembrane transport of Na~+, K~+, and Ca~(2+) by the cell membrane.