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目的 :观察肾移植术后受者T、B淋巴细胞及红细胞活性的变化并探讨其关系。方法 :测定 41例肾移植受者T、B淋巴细胞增殖反应及红细胞C3 b受体花环形成率 (C3 bRR)。结果 :T淋巴细胞增殖反应在术后 1～ 3周明显增强 ,7～ 8周减弱 ;B淋巴细胞增殖反应在术后 6～ 8周明显增强 ;急性排斥期间 ,T淋巴细胞增殖活性增强 ,未观察到B淋巴细胞增殖反应和红细胞C3 b受体活性的明显改变。术后红细胞活性逐渐增强 ,与血红蛋白的变化呈正相关 ,与淋巴细胞活性无明显相关关系。结论 :术后早期T淋巴细胞活性增强与移植物的刺激有关 ;动态观察T淋巴细胞增殖反应有助于急性排斥反应的诊断。术后B淋巴细胞活性逐渐增强的意义尚待阐明。红细胞活性测定是否可作为移植后免疫监测指标尚需进一步探讨
Objective: To observe the changes of T, B lymphocytes and erythrocyte activity in recipients after kidney transplantation and to explore their relationship. Methods: The T, B lymphocyte proliferative responses and the C3 b receptor rosette formation rate (C3 bRR) of 41 renal transplant recipients were determined. Results: The proliferative response of T lymphocytes increased significantly 1-3 weeks after operation and weakened at 7-8 weeks. The proliferative response of B lymphocytes increased significantly at 6-8 weeks after operation. The proliferative activity of T lymphocytes increased during acute rejection. Significant changes in B lymphocyte proliferation and erythrocyte C3b receptor activity were observed. Erythrocyte activity gradually increased after surgery, and changes in hemoglobin was positively correlated, and no significant correlation between lymphocyte activity. Conclusion: The early postoperative T lymphocyte activation is related to graft stimulation. Dynamic observation of the proliferation of T lymphocytes contributes to the diagnosis of acute rejection. The significance of postoperative B lymphocyte activity gradually enhanced remains to be elucidated. Whether the determination of erythrocyte activity can be used as an indicator of immune monitoring after transplantation still needs to be further explored