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本文报导了本院1973年1月至1983年3月284例晚期癌症病人用COPP方案治疗的结果。全组治疗效应率为66.3％,其中完全缓解者64人,部分缓解者125人。何杰金氏症,非何杰金氏症和小细胞肺癌患者的疗效率各为89.1％,71.7％和65.8％。中位缓解期各为23、17和10.5个月。全部病人随访率达90.5％。中位生存期各为49、43.5、12.5个月。3年生存率为47.8％,15％,和4.1％。5年生存率为15.2％,5.5％和2.7％。毒副作用主要表现为骨髓抑制和消化道反应,但其毒性甚微并可耐受。有短期肝功能不良和周围神经病,但可以恢复。无一病人死于毒副反应。
This article reports the outcome of 284 patients with advanced cancer treated with the COPD regimen from January 1973 to March 1983 in this hospital. The treatment effect rate in the whole group was 66.3%, including 64 complete remissions and 125 partial remissions. The rates of Hodgkin’s disease, non-Hodgkin’s disease, and small cell lung cancer patients were 89.1%, 71.7%, and 65.8%, respectively. The median remission period was 23, 17 and 10.5 months, respectively. The follow-up rate of all patients reached 90.5%. The median survival time was 49, 43.5, and 12.5 months. The 3-year survival rates were 47.8%, 15%, and 4.1%. The 5-year survival rates were 15.2%, 5.5%, and 2.7%. The main toxic and side effects are myelosuppression and gastrointestinal reactions, but their toxicity is minimal and tolerable. There is short-term liver dysfunction and peripheral neuropathy, but it can be restored. None of the patients died of toxic side effects.