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目的:探讨低频率低强度脉冲电磁场(PEMFs)治疗绝经后骨质疏松症(OP)大鼠安全性的影响。方法:3-5月龄雌性SD大鼠经手术分别摘取两侧卵巢(OVX),对照组实行假性去除卵巢手术(Sham),术后1月对手术组大鼠分组治疗,3个月后处死动物,对经过PEMFs照射治疗的大鼠进行全面观察,通过监测机体一般生命症状、重要脏器指数、血液生化学指标进行安全性评价。结果:通过一般体征、摄食量观察,血液生化指标检测、动物脏器解剖,经过统计学分析,发现经过为期3个月的治疗后,对大鼠的肝脏、肾脏功能没有明显影响,重要脏器指数与正常组没有差异,提示PEMFs照射对骨质疏松大鼠没有影响。结论:PEMFs照射治疗对于骨质疏松大鼠是安全的。
Objective: To investigate the effect of low-frequency low-intensity pulsed electromagnetic fields (PEMFs) on the safety of postmenopausal osteoporosis (OP) rats. Methods: Female ovariectomized rats (OVX) of 3 to 5 months old were randomly divided into control group (sham), sham operation group (sham group) After the animals were sacrificed, the rats treated with PEMFs irradiation were comprehensively observed, and the safety evaluation was conducted by monitoring the general vital signs, vital organs index and blood biochemical indexes. Results: Through the general signs, food intake observation, blood biochemical detection, animal organ anatomy, after statistical analysis, found that after 3 months of treatment, the rat liver and kidney function did not significantly affect the vital organs There was no difference between index and normal group, suggesting that PEMFs irradiation had no effect on osteoporosis rats. Conclusion: PEMFs irradiation is safe for osteoporosis rats.