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目的 观察大剂量环磷酰胺冲击治疗自身免疫病的长期疗效。方法 选择难治性或复发性原发性血小板减少性紫癜 4 0例 ,难治性或复发性自身免疫性溶血性贫血 10例 ,狼疮性肾炎或重症系统性红斑狼疮 2 0例 ,用CTX 0 5～ 1 5 g/m2 体表面积 ,快速静滴 ,2h滴完 ,同时嘱大量饮水 ,每 4周 1次 ,最多为 4次。治疗前后自身对照。结果 ITP、AIHA、SLE长期疗效上差异均有非常显著意义 (P <0 0 1)。总有效率87%。结论 研究结果表明 ,大剂量CTX冲击治疗自身免疫症长期疗效显著、安全、操作简便、经济适用。
Objective To observe the long-term efficacy of high-dose cyclophosphamide in the treatment of autoimmune diseases. Methods 40 cases of refractory or recurrent primary thrombocytopenic purpura, 10 cases of refractory or recurrent autoimmune hemolytic anemia, 20 cases of lupus nephritis or severe systemic lupus erythematosus were treated with CTX 0 5 ~ 1 5 g / m2 body surface area, rapid intravenous infusion, 2h drops finished, while expelling plenty of water, once every 4 weeks, up to 4 times. Self-control before and after treatment. Results The long-term effects of ITP, AIHA and SLE were all significantly different (P <0.01). The total efficiency of 87%. Conclusions The results show that long-term curative effect of high-dose CTX shock therapy for autoimmune diseases is significant, safe, easy to operate and economical.