在组织损伤或炎症的全身性反应过程——急性相应答中,由肝产生的某些糖蛋白在血浆中的浓度会增加,另一些糖蛋白则会减少。在小鼠肝细胞的原代培养中加入IL-1后,后者可影响许多急性应答相的特异性基因的表达。为了决定IL-1依赖的急性相基因表达调节的分子基础和组织特异性,作者将人肝细胞瘤Hep3B细 In the systemic response to tissue injury or inflammation - the acute response, some glycoproteins produced by the liver increase in plasma and others decrease in glycoproteins. After the primary culture of mouse hepatocytes with IL-1, the latter can affect the expression of specific genes for many acute phase responses. In order to determine the molecular basis and tissue specificity of IL-1-dependent regulation of acute phase gene expression, the authors compared Hep3B human hepatoma cells