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目的:观察女性生殖器尖锐湿疣复发与不复发患者的外周血Th1/Th2细胞因子水平,探讨其复发与其外周血Th1/Th2细胞因子的关系。方法:选取女性生殖器尖锐湿疣初发患者37例,经电灼治疗后随访3个月(期间不使用任何免疫制剂),根据是否复发分为复发A组15例和未复发B组22例。用ELISA法测定电灼治疗前各血清标本的细胞因子IL-2、IL-12、IL-4、IL-10的浓度,比较A、B两组血清各细胞因子及Th1/Th2比值的差异,分析尖锐湿疣复发与血清Th1/Th2细胞因子水平的关系。结果:尖锐湿疣复发与Th1/Th2比值呈显著负相关性。结论:尖锐湿疣复发与否与患者血清Th1/Th2细胞因子水平呈密切负相关。
Objective: To observe the levels of Th1 / Th2 cytokines in peripheral blood of female genital condyloma acuminatum patients with recurrent or non-recurrent genital warts, and to explore the relationship between the recurrence and Th1 / Th2 cytokines in peripheral blood. Methods: Thirty-seven cases of primary condyloma acuminatum were selected and followed up for 3 months after electrocautery treatment without any immunosuppressive agents. According to the relapse, 15 cases were divided into recurrence group A and non-recurrence group B, 22 cases. The concentrations of cytokines IL-2, IL-12, IL-4 and IL-10 in serum samples before and after electrocauterization were measured by ELISA. The differences of serum cytokines and Th1 / Th2 ratios in groups A and B were compared. To analyze the relationship between condyloma acuminatum recurrence and serum level of Th1 / Th2 cytokines. Results: Recurrence of condyloma acuminatum was negatively correlated with Th1 / Th2 ratio. Conclusion: The relapse of condyloma acuminatum is closely related to the level of serum Th1 / Th2 cytokines.