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目的探讨早产儿原发性呼吸暂停与血浆β内啡肽（β－ＥＰ）水平相关性。方法用放射免疫法测定出生后３～５天内发生原发性呼吸暂停早产儿和对照组（无疾患早产儿）血浆中β－ＥＰ水平。结果血浆β－ＥＰ水平重度组高于轻度组（Ｐ＜０．０１）。呼吸暂停后２４小时、第３天显著高于对照组（Ｐ＜０．００１），第６天仍高于对照组（Ｐ＜０．０５）。其血浆β－ＥＰ含量与动脉血ｐＨ值，ＰａＯ２呈明显负相关（ｒ＝０．８９８，０．７９８，Ｐ均＜０．０１）。结论表明血浆中β－ＥＰ水平增高与早产儿原发性呼吸暂停始发与复发密切相关，而呼吸暂停后酸中毒与低氧血症，又进一步刺激内啡肽入血，为早产儿原发性呼吸暂停奠定病理生理基础。
Objective To investigate the relationship between primary apnea and β-endorphin (β-EP) level in preterm infants. Methods The level of β-EP in the plasma of preterm infants with primary apnea and control group (non-diseased preterm infants) within 3 to 5 days after birth was measured by radioimmunoassay. Results Plasma β-EP level in severe group was higher than that in mild group (P <0.01). 24 hours after the apnea, the third day was significantly higher than the control group (P <0.001), the sixth day was still higher than the control group (P <0.05). The plasma β-EP content and arterial blood pH, PaO2 was significantly negatively correlated (r = 0.898,0.798, P <0.01). Conclusions: Plasma β-EP levels are closely associated with the onset and recurrence of primary apnea in preterm infants, whereas acidosis and hypoxemia after apnea further stimulate endorphins into the bloodstream, which is essential for the development of premature infants Sexual apnea laid the pathophysiology.