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目的观察阿司匹林(ASP)与异钩藤碱(Iso)合用对家兔体外血小板聚集的影响。方法通过体外血小板聚集实验,采用比浊法测定ASP与Iso合用对胶原(Col)、凝血酶(Thr)及二磷酸腺苷(ADP)诱发的家兔血小板聚集率的影响。结果ASP与Iso合用可抑制由Col(50mg·L-1)、Thr(3 U·m L-1)及ADP(15μmol·L-1)诱导的血小板聚集。结论 ASP与Iso合用能协同抑制家兔体外血小板聚集。
Objective To observe the effect of aspirin (ASP) combined with iso-rhynchophylline (Iso) on platelet aggregation in vitro in rabbits. Methods The effects of ASP and Iso on the platelet aggregation rate induced by Collagen (Col), thrombin (Thr) and adenosine diphosphate (ADP) in rabbits were determined by in vitro platelet aggregation assay and turbidimetry. Results ASP combined with Iso inhibited platelet aggregation induced by Col (50 mg · L -1), Thr (3 U · m L -1) and ADP (15 μmol·L -1). Conclusion The combination of ASP and Iso can inhibit the rabbit platelet aggregation in vitro.