论文部分内容阅读
1984年6月～1987年5月在本院行手术切除的120例垂体腺瘤中,经免疫细胞化学检查,发现2例垂体生长激素(GH)腺瘤病人缺乏明显肢端肥大症改变,而临床主要表现为闭经、泌乳综合征,现报告如下:例1,女,29岁。因闭经、泌乳3年,经头颅CT 检查证实为垂体腺瘤入院。术前血液内分泌学检查GH 值为3.4ng/ml,血清泌乳素(PRL)值为59.3ng/ml。经口、鼻、蝶窦切除1直径约1.0cm 的垂体肿瘤,病理诊断为嫌色性垂体腺瘤。肿瘤免疫细胞化学染色采用免疫金银法,显示肿瘤内存在大量GH 阳性细胞及少量的散在性PRL 阳性细胞。免疫细胞化学硷查诊断为GH 细胞腺瘤。
In 120 pituitary adenomas that were surgically resected from this hospital from June 1984 to May 1987, immunocytochemical examination revealed that 2 patients with pituitary growth hormone (GH) adenomas did not have obvious acromegaly changes. The main clinical manifestations of amenorrhea, lactation syndrome, are reported as follows: Case 1, female, 29 years old. Due to amenorrhea and lactation for 3 years, it was confirmed by head CT examination that a pituitary adenoma was admitted to hospital. Preoperative blood endocrinology had a GH value of 3.4 ng/ml and a serum prolactin (PRL) value of 59.3 ng/ml. A pituitary tumor with a diameter of 1.0 cm was removed by oral, nasal, and sphenoid sinus, and the pathological diagnosis was chromophobic pituitary adenoma. The immune immunocytochemical staining using immunogold-silver staining showed that there were a large number of GH-positive cells and a small amount of scattered PRL-positive cells in the tumor. Immunocytochemistry was used to diagnose GH cell adenomas.