目的 :建立高效液相色谱法测定尼索地平片含量及含量均匀度。方法 :色谱柱为C18柱 ,流动相为甲醇 -水 ( 65∶3 5) ,检测波长为 2 3 7nm ,地西泮为内标物。结果 :在 8～ 80 μg·mL- 1浓度范围内呈良好线性关系 ,平均回收率为 99 9% ,RSD =0 87%。结论 :该法专属性强 ,操作简便 ,结果准确 ,其分解产物亦可得到良好的分离 Objective: To establish HPLC method for the determination of nisoldipine tablet content and content uniformity. Methods: The chromatographic column was C18 column. The mobile phase consisted of methanol-water (65:35), detection wavelength was 23 7 nm and diazepam was the internal standard. Results: There was a good linear relationship in the concentration range of 8 ~ 80 μg · mL-1 with an average recovery of 99.9% and RSD = 0 87%. Conclusion: The method is highly specific, easy to operate, with accurate results, and its decomposition products can be well separated