目的:研究新型抗心律失常药甲苯喹哌对离子通道的作用.方法:通过膜片钳技术记录培养爪蟾胚胎肌细胞和神经细胞全细胞离子通道电流.结果:甲苯喹哌(0.1,1,10,100μmolL~(-1))可浓度依赖性地抑制肌细胞的钠通道,其IC_(50)为7.2μmol L~(-1)(5.3—9.8μmol L~(-1)).甲苯喹哌(10μmol L~(-1))可抑制神经细胞的高电压激活的钙通道.然而,肌细胞上的稳态外向钾电流却受到甲苯喹哌(10μmol L~(-1))的激活.结论:甲苯喹哌抑制钠、钙通道,但激活稳态外向钾通道. Objective: To study the effect of a novel antiarrhythmic drug, toluol, on ion channels.Methods: Whole cell ion channel current of muscle cells and nerve cells of Xenopus embryos were recorded by patch clamp technique.Results: 10,100 μmol L -1) inhibited the sodium channel of myocytes in a concentration-dependent manner with an IC 50 of 7.2 μmol L -1 (5.3-9.8 μmol L -1) (10 μmol L -1) inhibited the high voltage-activated calcium channel in nerve cells, however, the steady-state outward potassium current in muscle cells was activated by 10 μmol L -1. Toluene Quipah inhibits sodium and calcium channels but activates homeostatic potassium channels.