在组织细胞缺血缺氧时，葡萄糖无氧酵解造成乳酸堆积；而 Ａ Ｔ Ｐ 敏感钾通道开放，使细胞膜超极化，降低细胞兴奋性，起到对缺血缺氧的保护作用。乳酸作为缺血缺氧的代谢产物，一方面 Ｋ Ａ Ｔ Ｐ通道开放剂可引起其增加，而 Ｋ Ａ Ｔ Ｐ通道阻断剂则可减少其生成；另一方面，细胞内外乳酸却又可以激活 Ｋ Ａ Ｔ Ｐ通道，进一步加强其保护作用 In tissue ischemia and hypoxia, glucose anaerobic glycolysis caused lactic acid accumulation; and A T P-sensitive potassium channels open, the membrane hyperpolarization, reducing cell excitability, play a protective effect on ischemia and hypoxia. Lactate as a metabolite of ischemia and hypoxia, on the one hand KA T P channel opener can cause its increase, and K A T P channel blockers can reduce its production; the other hand, intracellular and extracellular lactate but can be activated K A T P channel, to further enhance its protective effect