论文部分内容阅读
目的探讨癌基因G-Fos、G-Jun表达产物与食管癌的发生、发展及预后的关系。方法应用免疫组织化学SABC法,以免抗G-Fos、G-Jun抗体标记60例食管瘤和10例远端切缘粘膜。观察其在切缘食管粘膜、癌旁粘膜及不同分化程度和组织学类型食管癌的表达,并比较其阳性率。结果G-Fol、G-Jun阳性反应见于癌旁粘膜和食管癌组织,癌旁粘膜G-Fos、C-Jun阳性率分别为72.2%和58.3%,癌组织为55.0%和48.3%;食管瘤表达的阳性率与癌组织分化程度和组织学类型有关(P<0.05),与淋巴结转移无关(P>0.05)。结论C-Fos、C-Jun的过量表达可发生在增生的食管粘膜和食管瘤组织,G-Fos、C-Jun可作为一种食管粘膜早期癌变和食管癌的生物学标记物。
Objective To investigate the relationship between the oncogene G-Fos and G-Jun expression products and the occurrence, development and prognosis of esophageal cancer. Methods Immunohistochemical SABC method was used to avoid labeling 60 cases of esophageal tumors and 10 cases of distal marginal mucosa with anti-G-Fos and G-Jun antibodies. Observe the expression of esophageal cancer in the margin of esophageal mucosa, paraneoplastic mucosa and different degree of differentiation and histological types, and compare the positive rate. Results G-Fol and G-Jun positive reactions were found in the paraneoplastic and esophageal cancer tissues. The positive rates of G-Fos and C-Jun in the adjacent mucosa were 72.2% and 58.3%, respectively, and the cancer tissues were 55.0%. And 48.3%; The positive rate of esophageal carcinoma expression was related to the differentiation degree and histological type of cancer tissue (P<0.05), but not related to lymph node metastasis (P>0.05). Conclusion Overexpression of C-Fos and C-Jun can occur in proliferating esophageal mucosa and esophageal neoplasms. G-Fos and C-Jun can be used as biological markers for early canceration and esophageal cancer in esophageal mucosa.