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目的探讨消化道肿瘤高发区甘肃省武威市食管癌发病危险因素。方法采用病例对照研究,在当地医院调查食管癌病例400例,正常对照752例,经单因素和多因素Logistic回归分析,筛选出与食管癌发病相关的可能危险因素。结果职业为农民、进食速度快、长期饮用蓄积水、进食腌制酸菜、吸烟、饮酒、萎缩性胃炎等与食管癌发病相关(其OR值分别为1.879、1.426、1.475、1.579、1.780、1.911、2.980),可增加其发病的危险性,而习惯性饮茶和良好的口腔卫生习惯为保护性因素(其OR值分别为0.663和0.708)。结论除去已经公认的致病因素,口腔卫生习惯不良也可能是该地食管癌发病不可忽视的危险因素之一,应针对上述因素采取综合防治措施。
Objective To investigate the risk factors of esophageal cancer in Wuwei City, Gansu Province, a high prevalence area of gastrointestinal cancer. Methods A case-control study was conducted. 400 cases of esophageal cancer and 752 normal controls were investigated in local hospitals. The possible risk factors related to the pathogenesis of esophageal cancer were screened out by single factor and multivariate Logistic regression analysis. Results The occupations were peasants, eating fast, drinking long-term accumulating water, eating pickled sauerkraut, smoking, drinking, atrophic gastritis and so on were associated with the incidence of esophageal cancer (OR values were 1.879,1.426,1.475,1.579,1.780,1.911, 2.980), can increase their risk of onset, and habitual drinking tea and good oral hygiene habits as a protective factor (OR values were 0.663 and 0.708, respectively). Conclusion The removal of the recognized causative factors and poor oral hygiene habits may also be one of the risk factors that can not be ignored in the esophageal cancer incidence in this area. Comprehensive prevention and treatment measures should be taken according to the above factors.