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本文对局部低温、低温平衡液附加其它药物灌注等五种保护缺血肾的方法,在13只狗的实验中进行了组织学及组织化学的初步观察和比较。实验结果表明:A 组(局部低温)、D 组(局部低温加肝素)及 E 组(局部常温)实验处理四小时内的不同间隔及停止处理后存活30～60天的取材标本中均显示了不可逆的组织学变化。琥珀酸脱氢酶、碱性磷酸酶、三磷酸腺苷酶均于实验处理1～2小时后开始减少,四小时后呈弱阳性或阴性反应,反应肾组织因缺血受损程度严重,说明这三种护肾措施对缺血肾保护作用不明显。B 组(低温灌注液加普鲁卡因及肝素灌注)实验处理时组织学及组织化学变化轻微,实验处理后60天所有变化基本恢复。C 组(低温灌注液加甘露醇、硫酸镁、ATP 及肝素灌注),实验处理时及处理后60天均未发现组织学及组织化学有异常变化,说明该组措施对缺血肾的保护效果较其余各组为佳。
In this paper, local hypothermia, hypothermia equilibration with other drug infusion of five methods to protect the ischemic kidney, 13 dogs in the experiment for the initial observation and comparison of histochemistry and histochemistry. The experimental results show that: A group (local hypothermia), D group (local low temperature plus heparin) and E group (local room temperature) within four hours of experimental treatment of different intervals and stop treatment after the survival of 30 to 60 days of the samples were shown Irreversible histological changes. Succinate dehydrogenase, alkaline phosphatase, adenosine triphosphatase in experimental treatment after 1 to 2 hours began to decrease, four hours after the weak positive or negative reaction, renal tissue damage caused by severe ischemia, indicating that the three Kidney protection measures of ischemic renal protection is not obvious. Group B (low temperature perfusate plus procaine and heparin perfusion) experimental treatment histological and histochemical changes slightly, 60 days after the experimental treatment all the changes recovered. There were no abnormal changes in histology and histochemistry in group C (hypothermic perfusate plus mannitol, magnesium sulfate, ATP and heparin perfusion). The experimental group had no abnormal changes in histology and histochemistry at 60 days after treatment, indicating that the protective effect of this group on ischemic kidney Better than the rest of the groups.