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1965年Pluznick等报告(1),在琼质培养基上进行小鼠骨髓干细胞培养时,底层放人肾细胞和胎儿细胞,可见到粒细胞集落和巨噬细胞集落的形成。由此推测.底层细胞可能分泌一种特异的活性物质,刺激粒细胞和巨噬细胞集落的形成,并将其命名为集落刺激因子(colony stimulating fa-ctor,CSF)。以后发现,CSF是一类具有刺激骨髓多能造血干细胞向粒单系祖细胞集落(CFU-C)分化,并使其发育为成熟粒细胞、巨噬细胞的体液性进血因子(2)。包括多能集落刺激因于mul-tipoient CSF,multi-CSF;interleukin3,IL-3),粒细胞一巨噬细胞集落刺激因子(granu-
In 1965, Pluznick et al. (1) reported that the formation of granulocyte colony and macrophage colony was observed when the mouse bone marrow stem cell culture was performed on the agar medium with the renal cells and fetal cells being released in the bottom layer. Therefore, it is speculated that the underlying cells may secrete a specific active substance to stimulate the formation of granulocyte and macrophage colony, and named colony stimulating fa-ctor (CSF). It was later found that CSFs are a class of humoral factors that contribute to the differentiation of bone marrow multipotent hematopoietic stem cells to granulocyte-monocyte progenitor colony (CFU-C) and to their development into mature granulocytes and macrophages (2). Including pluripotent colony stimuli due to mul-tipoient CSF, multi-CSF; interleukin 3, IL-3), granulocyte-macrophage colony stimulating factor