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成人心律失常治疗中发生奎尼丁晕厥及其有关因素已为人们所熟知,然而小儿资料尚少。本文比较服用奎尼丁的患儿的临床、解剖、心电图、放射学和药理学资料,以期确定影响奎尼丁晕厥发生率的因素。 Michigan大学Mott儿童医院心脏科在15年内收治355例快速心律失常,其中28例患儿使用奎尼丁至少2～3天并能耐受之。这些患儿在服药期间:6(男3、女3)例(21％,A组)曾发晕厥,22(男12,女10)例(79％,B组)未发生晕厥。器质性心脏病同奎尼丁晕厥有关(x~2=10.2,p=0.001)。A组6例(6/6)均有器质性心脏病,B组仅7例(7/22)患有器质性心脏
Quinidine syncope and its related factors have been well documented in the treatment of adult arrhythmia, however, there is little data available in children. This article compares the clinical, anatomic, electrocardiographic, radiological and pharmacological data of children taking quinidine to determine the factors that influence the incidence of quinidine syncope. Mott Children’s Hospital of the University of Michigan Department of Cardiology admitted to 355 cases of tachyarrhythmia within 15 years, of which 28 cases of children treated with quinidine for at least 2 to 3 days and can tolerate. During the course of medication, these children had syncope in 6 (male 3, female 3) (21%) and no syncope in 22 (male 12, female 10) (79%, group B). Organic heart disease with quizidine syncope (x ~ 2 = 10.2, p = 0.001). Six patients in group A (6/6) had organic heart disease, while in group B only seven patients (7/22) had organic heart