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目的:评价清毒益气汤辅于重组人干扰素α-2b凝胶外用治疗患者宫颈中重度不典型人乳头状瘤病毒(HPV)感染的临床疗效。方法:选取2013年3月—2014年9月间收治的宫颈中重度不典型HPV感染的阳性患者53例,依据CIN(Cervical Intraepithelial Neoplasia,宫颈上皮内瘤样病变)分级给予手术治疗,术后对照组患者给予重组人干扰素α-2b凝胶外用治疗,观察组患者在对照组治疗的基础上加用清毒益气汤(自拟方)治疗,两组患者均随访6月,比较两组患者治疗后的总有效率和HPV转阴率。结果:手术后,观察组患者治疗后的总有效率为73.08%高于对照组为62.96%(P<0.05),HPV转阴率为88.46%高于对照组为70.37%(P<0.05)。结论:采用清毒益气汤配合重组人干扰素α-2b凝胶外用治疗患者宫颈中重度不典型HPV感染患者的临床疗效优于单用重组人干扰素α-2b凝胶的疗效,且患者HPV转阴率高。
Objective: To evaluate the clinical effect of qingdu yiqi decoction supplemented with rhIFN α-2b gel in the treatment of patients with moderate-severe cervix severe atypical human papillomavirus (HPV) infection. Methods: Fifty-three patients with moderate-to-severe cervical atypical HPV infection were selected from March 2013 to September 2014. The patients were classified according to CIN (Cervical Intraepithelial Neoplasia, Cervical Intraepithelial Neoplasia), and postoperative control Patients in the observation group were treated with recombinant human interferon alfa-2b gel. The patients in the observation group were treated with qingdu yiqi decoction (self-prescribed) on the basis of the control group. Both groups were followed up for 6 months. The two groups were compared The total effective rate after treatment and HPV negative conversion rate. Results: After the operation, the total effective rate of the observation group was 73.08% higher than that of the control group (62.96%, P <0.05). The HPV negative conversion rate was 88.46% higher than that of the control group (70.37%, P <0.05). Conclusion: The clinical efficacy of qingdu yiqi decoction combined with rhIFN α-2b gel in the treatment of patients with moderate-to-severe cervical atypical cervix HPV infection is better than that of rhIFN α-2b gel alone. And the patients HPV turn negative rate.