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目的 探讨孕妇血清瘦素水平的变化及其与妊娠的关系。方法 采用放射免疫测定法 ,测定 2 5 1例孕妇 (观察组 )和 35例年龄、体重指数相近的正常非孕妇女 (对照组 )的血清瘦素水平 ,并将瘦素水平与孕妇的孕周、体重、体重指数、腹围、子宫底高度、血压等的关系进行了相关分析。结果 观察组瘦素水平为 (15 .1± 7.4) μg/L ,对照组瘦素水平为 (9.1± 4.9) μg/L ,两组比较 ,差异极有显著性 (P <0 .0 0 1)。相关分析显示 ,孕妇血清瘦素水平与其体重 (r =0 .5 2 9)、体重指数 (r =0 .5 5 1)、腹围 (r=0 .5 6 4)、子宫底高度 (r =0 .15 1)、收缩压 (r =0 .134 )、舒张压 (r=0 .2 5 1)均有相关性。妊娠期间 ,血清瘦素水平虽然逐渐上升 ,但直到孕 30周 ,统计学上尚无明显差异。结论 监测孕妇瘦素水平变化 ,对妊娠并发症 (如妊娠高血压综合征 )的临床观察可能有一定的意义
Objective To investigate the changes of serum leptin in pregnant women and its relationship with pregnancy. Methods Serum leptin levels were measured by radioimmunoassay in 25 pregnant women (observation group) and 35 normal non-pregnant women (control group) with similar age and body mass index. The levels of leptin in pregnant women , Body weight, body mass index, abdominal circumference, the height of the uterus, blood pressure and other related were analyzed. Results The leptin level in the observation group was (15.1 ± 7.4) μg / L and that in the control group was (9.1 ± 4.9) μg / L. There was significant difference between the two groups (P <0.01) ). Correlation analysis showed that serum leptin levels were positively correlated with body weight (r = 0.525), body mass index (r = 0.545), abdominal circumference (r = 0.564) = 0.1515), systolic blood pressure (r = 0.134) and diastolic blood pressure (r = 0.251). Although the level of serum leptin increased gradually during pregnancy, there was no statistically significant difference between the two groups until the third trimester of pregnancy. Conclusions Monitoring changes in leptin levels in pregnant women may have clinical implications for complications of pregnancy (eg, pregnancy-induced hypertension syndrome)