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在细胞内作为分子“伴侣”的热激蛋白(HSP)在细胞外具有免疫佐剂的活性,能够辅助其所“伴侣”的抗原分子激发抗原特异性免疫应答。此特性依赖于抗原提呈细胞的存在,尤其是树突状细胞(DC);其机制在于,HSP通过与TLR2/4、CD91等受体相互作用,激发抗原提呈细胞的炎性信号和抗原的交叉递呈。基于此特性,利用各种形式的HSP和抗原分子的复合抗原致敏DC是肿瘤免疫治疗的一个重要策略,已在大量基础和临床研究中得到了良好的验证。然而,含有HSP的复合抗原致敏的DC,具有制备成本高、质控和检定复杂以及安全性风险
Heat shock proteins (HSPs), which act as molecules / “chaperones” in cells, have extracellular immune adjuvant activity and can assist antigen molecules in their “chaperones” to stimulate antigen-specific immune responses. This characteristic depends on the presence of antigen presenting cells, especially dendritic cells (DCs); its mechanism is that HSPs stimulate the inflammatory signals and antigens of antigen-presenting cells by interacting with TLR2 / 4, CD91 and other receptors Cross presentation. Based on this property, DC sensitization using various forms of HSPs and antigen molecules is an important strategy for tumor immunotherapy and has been well verified in a great number of basic and clinical studies. However, DCs sensitized with HSPs containing HSPs have high preparation cost, quality control and verification complexity and safety risk