芪胶升白胶囊对非霍奇金淋巴瘤患者化疗后骨髓抑制的治疗作用观察

来源 :中华中医药学刊 | 被引量 : 0次 | 上传用户:cysyzcws
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:观察芪胶升白胶囊对非霍奇金淋巴瘤患者化疗后骨髓抑制的治疗作用。方法:选取医院肿瘤科2012年1月—2016年1月收治的非霍奇金淋巴瘤患者324例,随机分为观察组(CHOP化疗方案+芪胶升白胶囊)与对照组(CHOP化疗方案),治疗4个周期后,观察两组患者的临床疗效、骨髓抑制及不良反应发生情况。结果:观察组患者总缓解率为58.60%,高于对照组的57.14%,两组患者见的总缓解率比较不具有统计学差异(P<0.05)。治疗结束后,观察组中重度骨髓抑制发生率为2.55%(4/157),显著低于对照组的15%(21/140);治疗结束1周后,观察组中重度骨髓抑制发生率为3.18%(5/157),显著低于对照组的17.14%(24/140),差异具有统计学意义(P<0.05)。观察组患者白细胞计数最低值为(2.61±0.57)×10~9/L,高于对照组的(1.21±0.31)×10~9/L,差异具有统计学意义(P<0.05);两组患者血红蛋白计数、血小板计数最低值比较无统计学差异(P<0.05)。治疗中,观察组患者有3(1.91%)例由于不良反应严重退出试验,对照组患者18(12.86%)例不良反应严重退出试验,观察组由于不良反应退出试验患者显著低于对照组(P<0.05)。治疗后,观察组患者贫血、感染及恶心呕吐的发生情况均显著低于对照组,差异具有统计学意义(P<0.05)。结论:芪胶升白胶囊能够改善恶性淋巴瘤患者骨髓抑制情况,降低不良反应发生率,保证化疗顺利进行,值得临床推广使用。 OBJECTIVE: To observe the therapeutic effect of QGLB on myelosuppression in patients with non-Hodgkin’s lymphoma after chemotherapy. Methods: A total of 324 patients with non-Hodgkin’s lymphoma admitted from January 2012 to January 2016 in the hospital oncology department were randomly divided into observation group (CHOP chemotherapy + Shengjisheng capsule) and control group (CHOP chemotherapy ). After 4 cycles of treatment, the clinical efficacy, bone marrow suppression and adverse reactions of the two groups were observed. Results: The total remission rate in observation group was 58.60%, which was higher than that in control group (57.14%). There was no significant difference between the two groups (P <0.05). After the treatment, the incidence of severe myelosuppression in the observation group was 2.55% (4/157), which was significantly lower than that in the control group (21/140). One week after the end of treatment, the incidence of severe myelosuppression in the observation group was 3.18% (5/157), which was significantly lower than that of the control group (17.14%, 24/140). The difference was statistically significant (P <0.05). The lowest value of leukocyte count in observation group was (2.61 ± 0.57) × 10 ~ 9 / L, which was significantly higher than that in control group (1.21 ± 0.31) × 10 ~ 9 / L Patients with hemoglobin count, the lowest platelet count was no significant difference (P <0.05). During the treatment, 3 (1.91%) patients in the observation group quit their trial seriously due to adverse reactions, and 18 (12.86%) patients in the control group quit their tests seriously. Patients in the observation group quit due to adverse reactions were significantly lower than those in the control group <0.05). After treatment, the occurrence of anemia, infection and nausea and vomiting in observation group were significantly lower than those in control group (P <0.05). Conclusion: QGJP can improve myelosuppression in patients with malignant lymphoma, reduce the incidence of adverse reactions and ensure the smooth progress of chemotherapy, which is worthy of clinical promotion and use.
其他文献
小学音乐欣赏教学中声势律动的应用,主要是音乐与肢体律动进行结合的一种教学方式,其与传统单一的音乐欣赏教学相比,配合肢体动作,更能够使学生感受到音乐的节奏感、韵律感等
日前,现代汽车发布了一款全新概念电动车Prophecy.寓意为“预言”的它,既承载了现代汽车“乐观未来主义”的内涵,又代表了现代汽车最新的设计语言和设计理念.rn作为继“45”
期刊
基本医疗保险作为社会保障的重要组成部分,对完善我国社会保障制度、维护社会的稳定有着举足轻重的作用。我国的医疗保险制度改革历经“两江式”、“海南式”和“深圳式”等模
就像抗生素一样,没有人能够确定哪一种物质或添加剂可以取代仔猪日粮中的氧化锌.我们需要对造成哺乳仔猪断奶时腹泻的原因进行更深入的调查,重点研究方向包括仔猪肠道菌群组
高校要重视大学生的闲暇生活,对大学生要进行闲暇教育及引导已经成为大家的共识.本文从闲暇生活对大学生的影响入手,结合大学新生入学教育现状,提出针对大学新生的闲暇教育及
美术是中学教育教学的关键构成部分,对中学生审美水平的培养、人文涵养的提高具有非常关键的促进和推动作用,而传统文化属于中国民族精神、传统文化底蕴的关键体现,在中学美
目的提高对前列腺小细胞神经内分泌癌的认识。方法报告1例86岁高龄前列腺小细胞神经内分泌癌患者,有血尿伴排尿困难症状,肛指检查示前列腺增生,质地中等,前列腺特异性抗原(PS
在我国社会和经济转型时期,各种危机事件频繁发生。如何完善政府公共危机过程管理,提高政府应对公共危机的能力,保障人民的生命和财产安全,成为建设服务型政府的目标,积极应对并解
了解猪舍内的空气流动特性有助于猪场在猪舍内更好地应用适宜的通风措施.养猪管理专家John Gadd对此进行了详细的解释,并向广大猪场推荐猪舍通风的7条规则.
随着高校教育体制改革的不断深入发展,招生规模的日益扩大,学生作为高校的另一个主体,与其相关的各项收费和发放工作也必然是高校学生工作的主要内容,这关系到学生的切身利益