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目的探讨不同年龄段冻融胚胎移植周期子宫内膜厚度及类型与妊娠结局的关系。方法将336例冻融胚胎移植患者按年龄分<35岁(Ⅰ组)、≥35岁且<40岁(Ⅱ组)及≥40岁(Ⅲ组)3组;(1)依照转化日子宫内膜厚度分为a组:子宫内膜厚度≤7.0 mm;b组>7 mm且≤12.0 mm;c组>12 mm 3组:比较亚组间妊娠结局的差异;(2)依照妊娠结局分组,比较子宫内膜厚度及类型组间的差异。结果各自年龄段中(1)Ⅰb组和Ⅰc组临床妊娠率显著高于Ⅰa组(P<0.05);Ⅱ组和Ⅲ组,b、c组临床妊娠率均优于a组(P>0.05)。(2)Ⅱ组,对比未孕组,临床妊娠组转化日内膜A型率显著更高(P<0.05),内膜呈现A至C形态比例较高,差异但无统计学意义(P>0.05);Ⅲ组对比未孕组,临床妊娠组内膜呈现A至C形态比例显著更高(P<0.05),转化日内膜A型率更高(P>0.05)。结论子宫内膜厚度>7 mm和年龄稍长(≥35岁)患者转化日内膜具有A型及内膜形态变化功能较好的妊娠结局可能更好。
Objective To investigate the relationship between the endometrial thickness and the type of pregnancy and the outcome of frozen-thawed embryo transfer in different age groups. Methods 336 patients with frozen-thawed embryo transfer were divided into three groups according to their age <35 years (group Ⅰ), ≥35 years old <40 years old (group Ⅱ) and ≥40 years old (group Ⅲ). (1) Film thickness was divided into group a: endometrial thickness ≤7.0 mm; group b> 7 mm and ≤12.0 mm; group c> 12 mm 3: comparison of differences in pregnancy outcome among subgroups; (2) Differences in endometrial thickness and type were compared. Results The clinical pregnancy rates in group Ⅰb and group Ⅰc were significantly higher than those in group Ⅰa (P <0.05). The clinical pregnancy rates in group Ⅱ, group Ⅲ and group Ⅲ were significantly higher than those in group Ⅰ (P0.05) . (2) In group Ⅱ, compared with non-pregnant group, the rate of type A in endometrial in clinical pregnancy group was significantly higher (P <0.05), and the ratio of A to C in endometrium was higher, but the difference was not statistically significant (P> 0.05). The ratio of A to C in clinical pregnancy group was significantly higher in group Ⅲ than that in non-pregnant group (P <0.05), and the rate of type A in endometrium was higher on the day of transformation (P> 0.05). Conclusions Patients with endometrial thickness> 7 mm and slightly longer age (≥35 years) may have better outcome in the endometrial transformation with type A and endometrial morphology.