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目的探讨将经尿道置管的尿动力学检测方法应用于大鼠压力性尿失禁模型尿动力学研究的可行性和有效性,并分析大鼠尿道括约肌功能障碍的尿动力学特征。方法12只成年雌性未育大鼠在模拟产伤致尿道括约肌损伤前及损伤后第14天经尿道置管行充盈期膀胱压力、漏尿点压力和静态尿道压力测定。结果10只顺利完成实验。损伤前平均最大膀胱容量、排尿压、腹压漏尿点压、最大尿道压、最大尿道闭合压分别为(0.88±0.46)ml、(26.50±6.42)cmH2O(1 cmH2O=0.098 kPa)、(25.65±5.47)cmH2O、(14.80±2.78)cmH2O和(13.10±2.60)cmH2O,损伤后分别为(1.47±0.69)ml、(17.10±6.74)cmH2O、(15.55±5.24)cmH2O、(12.10±3.07)cmH2O和(10.60±3.20)cmH2O,大鼠膀胱最大容量增加(0.60±0.40)ml(P<0.01),排尿压、腹压漏尿点压分别下降(9.40±8.74)cmH2O、(9.50±4.92)cmH2O(P<0.01),最大尿道压和最大尿道闭合压亦下降(2.70±3.37)cmH2O、(2.50±2.59)cmH2O(P<0.05)。结论模拟产伤可有效建立雌性大鼠压力性尿失禁模型,经尿道置管的尿动力学检测方法能客观评价大鼠尿道括约肌功能。
Objective To investigate the feasibility and effectiveness of transurethral catheterization of urodynamics in the urodynamic study of stress urinary incontinence in rats and to analyze the urodynamic characteristics of dysfunctional urethral sphincter in rats. Methods 12 adult female unfertilized rats were tested for bladder pressure, leakage pressure and static urethral pressure before and during the urethral sphincter injury injury simulation on the 14th day after trauma. Results 10 successfully completed the experiment. The mean maximum bladder volume, urinary pressure, abdominal pressure, maximal urethral pressure and maximum urethral pressure before injury were (0.88 ± 0.46) ml, (26.50 ± 6.42) cmH2O (1 cmH2O = 0.098 kPa) (1.47 ± 0.69) ml, (17.10 ± 6.74) cmH2O, (15.55 ± 5.24) cmH2O and (12.10 ± 3.07) cmH2O, respectively (± 5.47 cmH2O, (14.80 ± 2.78) cmH2O and (9.40 ± 8.74) cmH2O and (9.50 ± 4.92) cmH2O, respectively (P <0.01). Compared with the control group, the maximal volume of bladder increased (0.60 ± 0.40) ml (2.70 ± 3.37) cmH2O and (2.50 ± 2.59) cmH2O, respectively (P <0.01). The maximum urethral pressure and maximal urethral closure pressure also decreased (P <0.05). Conclusion Simulated wound injury can effectively establish the stress urinary incontinence model in female rats. Urinary catheter dynamic test can objectively evaluate the urethral sphincter function in rats.