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目的 :为研究CYP2C19基因在中国云南地区特色少数民族独龙族人群中的基因型及突变频率 .方法 :采用聚合酶链式反应 (PCR)与限制性内切酶片段长度多态性(RFLP)技术分析了 2 0 5例独龙族人群中的基因型 .结果 :84人为CYP2C19野生型纯合子 (wt/wt) ;98人为CYP2C19m1杂合子 (wt/m1)
Objective: To investigate the genotype and mutation frequency of CYP2C19 gene in Dulong nationality with ethnic minorities in Yunnan, China.Methods: Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) The genotypes of 205 Duronians were analyzed.Results: 84 were CYP2C19 wild-type homozygotes (wt / wt), 98 were CYP2C19m1 heterozygotes (wt / ml)