论文部分内容阅读
目的了解维持性血液透析(MHD)患者维生素D水平与心脏功能的关系。方法选择43例透析时间>3个月、病情稳定、已排除急性心血管事件的血液透析患者(MHD组),检测血浆25(OH)D及脑钠肽(BNP)水平,同时应用心脏超声心动图测定左室射血分数(LVEF)、左心室舒张末内径(LVDd)、室间隔厚度(IVST)、左心室后壁厚度(LVPWT),计算左心室心肌重量指数(LVMI),分析MHD患者血浆25(OH)D水平及25(OH)D缺乏与心脏结构和功能的关系。另选择健康人群20例作为对照组。结果 MHD组25(OH)D水平较对照组降低[(34.74±16.17)nmol/Lvs.(53.23±21.85)nmol/L](P<0.01)。以≤50nmol/L为维生素D缺乏,MHD患者维生素D缺乏患者35例(81.4%)。25(OH)D浓度与BNP、LVMI呈负相关,与LVEF值呈正相关。结论 MHD患者维生素D缺乏的患病率较肾功能正常组明显增高,维生素D为影响心脏结构和功能的独立危险因素。
Objective To investigate the relationship between vitamin D levels and cardiac function in maintenance hemodialysis (MHD) patients. Methods Forty-three hemodialysis patients (MHD group) with stable dialysis and acute cardiovascular events were enrolled in this study. The plasma levels of 25 (OH) D and BNP were measured in 43 patients with dialysis for more than 3 months. Cardiac echocardiography The left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVDd), interventricular septum thickness (IVST) and left ventricular posterior wall thickness (LVPWT) were measured to calculate the left ventricular myocardial mass index 25 (OH) D levels and 25 (OH) D deficiency and cardiac structure and function of the relationship. Another 20 healthy people choose as the control group. Results The level of 25 (OH) D in MHD group was lower than that in control group [(34.74 ± 16.17) nmol / L vs (53.23 ± 21.85) nmol / L], P <0.01. To ≤ 50nmol / L for vitamin D deficiency, MHD patients with vitamin D deficiency in 35 patients (81.4%). The concentration of 25 (OH) D was negatively correlated with BNP and LVMI and positively correlated with LVEF. Conclusions The prevalence of vitamin D deficiency in patients with MHD was significantly higher than that in patients with normal renal function. Vitamin D was an independent risk factor for cardiac structure and function.