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目的观察单纯疱疹病毒(HSV)感染与心房颤动(房颤)的相关性。方法严格筛选103例孤立性房颤患者,分为阵发性房颤组74例和持续性房颤组29例,从流行病学对照研究队列中选取72例未合并房颤的健康人群作为对照组。空腹采集静脉血,用ELISA法按试剂盒标准流程检测血清HSV1 IgG抗体、HSV2 IgG抗体水平;运用相关分析探讨患者血清高敏C反应蛋白(hs-CRP)水平与HSV1 IgG抗体、HSV2 IgG抗体滴度的关系。结果对照组、阵发性房颤组和持续性房颤组的血清HSV1 IgG抗体水平分别为(217.95±53.18)μg/ml、(304.76±57.58)μg/ml和(322.99±60.35)μg/ml,血清HSV2 IgG抗体水平分别为(307.25±64.02)μg/ml、(407.22±59.1)μg/ml和(406.63±50.67)μg/ml,hs-CRP水平分别为(2.16±0.70)mg/L、(3.90±0.59)mg/L和(3.90±0.63)mg/L;对照组的血清HSV1 IgG抗体、HSV2 IgG抗体、hs-CRP水平均显著低于阵发性房颤组和持续性房颤组(均P<0.001);阵发性房颤组与持续性房颤组的血清HSV1 IgG抗体、HSV2 IgG抗体、hs-CRP水平比较,差异均无统计学意义(均P>0.05)。血清HSV IgG抗体水平与hs-CRP水平呈正相关关系(rHSV1=0.532,P<0.001;r_(HSV2)=0.446,P<0.001)。结论房颤患者的血清HSV IgG抗体水平显著升高,且与血清hs-CRP水平呈正相关。
Objective To investigate the correlation between herpes simplex virus (HSV) infection and atrial fibrillation (atrial fibrillation). Methods A total of 103 patients with isolated atrial fibrillation were screened strictly. They were divided into 74 cases of paroxysmal atrial fibrillation group and 29 cases of persistent atrial fibrillation group. 72 healthy volunteers without epidemic of AF were selected from the epidemiological control cohort group. Serum HSV1 IgG and HSV2 IgG antibodies were detected by ELISA according to the kit’s standard procedure. The serum levels of hs-CRP and HSV1 IgG antibody titers Relationship. Results The levels of serum HSV1 IgG in the control group, paroxysmal atrial fibrillation group and persistent AF group were (217.95 ± 53.18) μg / ml, (304.76 ± 57.58) μg / ml and (322.99 ± 60.35) μg / ml , And serum hs-CRP levels were (307.25 ± 64.02) μg / ml, (407.22 ± 59.1) μg / ml and (406.63 ± 50.67) μg / (3.90 ± 0.59) mg / L and (3.90 ± 0.63) mg / L, respectively. The levels of serum HSV1 IgG, HSV2 IgG and hs-CRP in the control group were significantly lower than those in the atrial fibrillation group and the persistent atrial fibrillation group (All P <0.001). There was no significant difference in serum HSV1 IgG antibody, HSV2 IgG antibody and hs-CRP between patients with paroxysmal atrial fibrillation and persistent AF (all P> 0.05). Serum HSV IgG antibody levels and hs-CRP levels were positively correlated (rHSV1 = 0.532, P <0.001; r HSV2 = 0.446, P <0.001). Conclusion The serum level of HSV IgG in patients with atrial fibrillation is significantly higher than that in patients with atrial fibrillation, which is positively correlated with the level of serum hs-CRP.