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Topliss和Bond报告过1例成人用心得安治疗后出现急性脑综合征,作者也见1例12岁女孩因高血压和淋巴瘤用心得安治疗发生相同并发症。患者经腹部照射治疗及抗癌化疗后,身体情况有改善,口服心得安10mg,8小时一次,共3次及15mg每8小时一次,共5次以控制高血压。共服8剂(在64小时内共用105mg,后发生定向力障碍、激动伴持续喃喃自语,后进入昏迷状态但无局部体征。患者普遍反射增高,两侧对称性Babinski征,持续性踝膝阵挛等。腰脊液初压165mm,葡萄糖63mg/dl、蛋白
Topliss and Bond reported that one adult developed acute brain syndrome after treatment with propofol. The authors also found that a 12-year-old girl developed the same complications of prophylactic treatment of hypertension and lymphoma. After treatment of patients with abdominal and anti-cancer chemotherapy, the body condition has improved, oral propranolol 10mg, 8 hours, a total of 3 times and 15mg every 8 hours, a total of 5 times to control high blood pressure. A total of 8 doses (105mg in 64 hours, after the occurrence of disorientation, agitation with sustained murmur, and then into the coma without local signs. Patients generally increased reflexes, bilateral symmetry Babinski sign, persistent ankle Knee clonus, etc. L4 spinal fluid pressure, 63mg / dl glucose, protein