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目的:探究奥拉西坦结合叶酸及维生素B12治疗老年2型糖尿病合并轻度认知功能障碍的临床疗效。方法:择取过去一年(2015.6-2016.5)我院神经内科接受治疗的64例2型糖尿病合并轻度认知功能障碍患者进行回顾分析,随机分至对照、观察两组。对照、观察两组分别行单纯奥拉西坦治疗以及奥拉西坦+叶酸及维生素B12治疗方法,对二者疗效差异进行探究。结果:无论在2型糖尿病合并轻度认知功能障碍患者的日常生活能力量表(ADL)评分方面,还是在其自身同型半胱氨酸(HCY)、叶酸及维生素B12水平以及治疗后的蒙特利尔认知评估量(Mo CA)评分等方面,联合用药的观察组均明显优于对照组,P<0.05,统计学意义明显。结论:奥拉西坦结合叶酸及维生素B12可以对老年2型糖尿病合并轻度认知功能障碍患者的治疗起到帮助,对患者认知功能的恢复和生活质量的提高有很明显的帮助,可以有效提高治疗效果并控制疾病的负面反应。
Objective: To investigate the clinical efficacy of oxiracetam combined with folic acid and vitamin B12 in the treatment of senile type 2 diabetes with mild cognitive impairment. Methods: Sixty-four patients with type 2 diabetes mellitus with mild cognitive impairment treated in our department of neurology in the past year (2015.6-2016.5) were retrospectively analyzed and randomly divided into two groups. Control, observe the two groups were treated with simple oxiracetam and oxiracetam + folic acid and vitamin B12 treatment, to explore the differences between the two efficacy. RESULTS: No matter in patients with type 2 diabetes mellitus with mild cognitive impairment, ADL scores, or in their own homocysteine (HCY), folic acid and vitamin B12 levels and after treatment in Montreal Cognitive assessment (MoCA) score, the combination of observation group were significantly better than the control group, P <0.05, statistically significant. Conclusion: Oxiracetam in combination with folic acid and vitamin B12 may be helpful in the treatment of elderly patients with type 2 diabetes mellitus complicated with mild cognitive impairment, and may be helpful in the recovery of cognitive function and quality of life in patients with Effectively improve the therapeutic effect and control the negative reaction of the disease.