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肿瘤的长大需要新血管的生成,其中浸润性内皮细胞还具有刺激肿瘤的生长因子,定量测定血管生成可以作为预测淋巴结阴性结肠癌预后的指标。作者采用免疫过氧化酶技术(Am J Clin Pathol 1986;85:269)对105例Astler Coller B2期结肠腺癌的石蜡标本作内皮细胞因子Ⅷ相关抗原的免疫染色,按内皮细胞染色作出血管生成的分级(1～4级)和计分,分析临床资料和病理检查结果,术后进行随访至少5年。 经统计血管生成分级与计分(AS)密切相关。在全组105例中,57例在随访期仍生存,3例病人于术
The growth of tumors requires the generation of new blood vessels. Infiltrating endothelial cells also have growth factors that stimulate tumors. Quantitative determination of angiogenesis can be used as an index to predict the prognosis of negative node-negative colon cancers. The authors used immunoperoxidase technology (Am J Clin Pathol 1986; 85: 269) to immunostain 105 cases of Astler Coller B2 colon adenocarcinoma paraffin-embedded by endothelial cell factor VIII related antigens and stained by endothelial cells to make angiogenesis. Grading (grade 1 to 4) and scoring, analysis of clinical data and pathological findings, follow-up for at least 5 years after surgery. Statistical angiogenesis grading is closely related to scoring (AS). Of the 105 patients in the entire group, 57 survived during follow-up and 3 patients