人类呼出气一氧化碳(NO)的来源尚不十分清楚,最近的研究提示可能主要来源于鼻部气道。作者在长期气管切开的清醒病人,通过测定三种不同部位(鼻、口和气管切开处)呼出气NO水平研究其来源,并探讨纤毛功能受损的Kartagener’s综合征患儿呼出气NO的变化。 患者和方法受试者分为四组:①健康儿童20名(3～13岁);②Kartagener’s综合征(包括内脏转位、副鼻窦炎和支气管扩张症)患儿4例(2.5～12岁);③因气管狭窄或喉癌而长期气管切开的非吸烟患者4例 The source of the human exhaled carbon monoxide (NO) is not well understood, and recent studies suggest that it may originate mainly from the nasal airways. In a long-term, tracheotomy conscious patient, the origin of exhaled NO was examined by measuring three different sites (nasal, oral, and tracheotomy), and the origin of exhaled NO in children with impaired ciliary dysfunction Variety. Patients and Methods Subjects were divided into four groups: ① 20 healthy children (3-13 years); ② 4 children (2.5-12 years old) with Kartagener’s syndrome (including visceral transposition, sinusitis and bronchiectasis) ; ③ due to tracheal stenosis or laryngeal cancer and long-term tracheotomy in 4 patients with non-smoking