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The mast cell is an enigmatic cell type whose physiologicalfunction has preoccupied large numbers of investigators fordecades.Some have concluded that the absence of mast cellsis incompatible with life,at least in humans,because no humanconditions have been documented where these cells are absentfrom the body.On the other hand,mice harboring specificmutations in certain growth factors,or their receptors,that leadto apparently an almost total ablation of the mast cell lineage,are viable,although they do have several documentedabnormalities and may exhibit altered inflammatory responses
The mast cell is an enigmatic cell type whose investigator for decades.Some have accounts that the absence of mast cellsis incompatible with life, at least in humans, because no humanconditions have been documented where these cells are absentfrom the body. On the other hand, mice harboring specific mutants in certain growth factors, or their receptors, that lead to apparently an almost total ablation of the mast cell lineage, are viable, although they do have several documented abnormalities and may exhibit altered inflammatory responses