[目的]探讨自拟“祛息”方联合美沙拉嗪治疗溃疡性结肠炎假性息肉的临床效果及安全性评价。[方法]选择我院消化内科于2014年1月~2016年6月间接收的溃疡性结肠炎假性息肉患者56例作为研究对象,按照随机数字表法,将患者随机均分为观察组和对照组,每组各28例,所有患者根据便血、腹痛、腹泻等症状给予对症治疗,对照组在对症治疗的基础上给予美沙拉嗪缓释颗粒治疗,观察组患者在对症治疗和口服美沙拉嗪缓释颗粒的基础上加用自拟“祛息”方治疗,评价比较2组患者治疗前后息肉数目、息肉直径和息肉黏膜损伤程度的变化以及总体治疗效果和治疗安全性。[结果]治疗前,2组患者的息肉数目、息肉直径和息肉黏膜损伤程度评分并无明显差异,P>0.05,差异无统计学意义,但是治疗后,观察组明显低于对照组,P<0.05,差异有统计学意义;观察组患者治疗有效率96.43%,对照组治疗有效率为75.00%,观察组明显高于对照组,P<0.05,差异有统计学意义;2组患者治疗期间均未出现肝肾功能损害、凝血功能障碍以及恶心、呕吐、皮疹等不良反应情况。[结论]自拟“祛息”方联合联合美沙拉嗪治疗溃疡性结肠炎假性息肉疗效显著,能够显著的降低患者的息肉数量、体积以及结肠黏膜损伤程度,提高患者的临床治疗效果,同时安全性好,临床值得推广应用。 [Objective] To investigate the clinical effect and safety evaluation of self-made “Qi Mu” prescription combined with Mesalazine in the treatment of pseudo-polyps of ulcerative colitis. [Methods] Fifty-six patients with ulcerative colitis pseudo-polyp received from Department of Gastroenterology in our hospital from January 2014 to June 2016 were selected as research objects. According to the random number table method, patients were randomly divided into observation group and control group Control group, each group of 28 cases, all patients according to blood in the stool, abdominal pain, diarrhea and other symptoms given symptomatic treatment, the control group on the basis of symptomatic treatment was given mesalazine sustained-release particles treatment, the observation group of patients in symptomatic treatment and oral mesala The results showed that the number of polyps, the diameter of polyps and the degree of polyp mucosal injury changes before and after treatment were compared and the overall treatment effect and treatment safety were compared between the two groups. [Results] Before treatment, there was no significant difference between the two groups in the number of polyps, the diameter of polyps and the degree of polyp mucosal injury. There was no significant difference between two groups (P> 0.05), but after treatment, the observation group was significantly lower than the control group (P < 0.05, the difference was statistically significant; the effective rate of the treatment group was 96.43% in the observation group and 75.00% in the control group, the observation group was significantly higher than the control group, P <0.05, the difference was statistically significant; both groups during the treatment period There was no liver and kidney dysfunction, coagulation disorders and nausea, vomiting, rash and other adverse reactions. [Conclusion] Treatment of ulcerative colitis pseudo- polyps with self-made “Qi Mu” prescription combined with mesalazine has a significant curative effect, which can significantly reduce the number of patients with polyps, the volume and the degree of colonic mucosal injury, and improve the clinical efficacy of the patients , While good safety, clinical worth promoting application.