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自发性细菌性腹膜炎(SBP)是肝硬化腹水患者的严重并发症,发生率高达8～15%。作者等对22例经肝组织学和(或)临床、生化检测诊断的肝硬化患者发生的27次SBP,应用羟氨苄青霉素及具有强力抑制β-内酰胺酶活性的棒酸(clavulanic acid)进行前瞻性联合治疗研究及评价其近期疗效和一年预后。并测定血清和腹水中的药物浓度,以了解其生物利用度。患者中有6例合并恶性肿瘤,其中肝癌4例、乳腺癌和来源不明的腺癌各1例。大多数患者有黄疸、体温调节紊乱、腹痛、脑病、腹泻,仅1例无临床症状。17例次(63%)腹水中分离出细菌,其腹水中的多
Spontaneous bacterial peritonitis (SBP) is a serious complication of patients with cirrhosis and ascites, the incidence of up to 8 to 15%. The authors studied 27 SBP episodes in 22 cirrhotic patients diagnosed by liver histology and / or clinical and biochemical tests using amoxicillin and clavulanic acid with potent β-lactamase activity Prospective combination therapy research and evaluation of its immediate effect and one-year prognosis. The concentration of the drug in serum and ascites was measured to find out its bioavailability. There were 6 patients with malignant tumor, including 4 cases of liver cancer, 1 case of breast cancer and 1 case of adenocarcinoma of unknown origin. Most patients have jaundice, temperature regulation disorders, abdominal pain, encephalopathy, diarrhea, only 1 case no clinical symptoms. Bacteria were isolated in 17 cases (63%) of ascites, with more in ascites