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应用ＲＩＡ法系统测定１５例胎儿中枢神经系统（ＣＮＳ）组织中的生长抑素（ＳＳ）和胃动素（ＭＴＬ）含量。发现人胚胎ＣＮＳ各组织中均有不同浓度的ＳＳ及ＭＴＬ存在，ＳＳ浓度普遍高于ＭＴＬ（Ｐ＜０．０１），其中ＳＳ含量以下丘脑最高（Ｐ＜０．０１），ＭＴＬ水平各组织间无显著性差异，在垂体ＭＴＬ出现早于１６周，ＳＳ晚于２２周，其它部位则ＳＳ出现早于１６周，ＭＴＬ晚于２２周。随胚胎发育，ＳＳ的发展呈不同趋势：①下丘脑ＳＳ浓度与胎龄呈正相关（ｒ＝０．７３４５，Ｐ＜０．０１）。②垂体、延髓与脊髓ＳＳ波动在一定水平，无显著变化。③大脑皮层和小脑ＳＳ呈先升高后下降趋势，ＭＴＬ的发展则随胎龄呈一致性升高。提示人胎儿的ＣＮＳ中ＳＳ与ＭＴＬ的发生，发展及分布存在不同规律。
The contents of somatostatin (SS) and motilin (MTL) in 15 cases of fetal central nervous system (CNS) tissues were determined by RIA method. It was found that there were SS and MTL concentrations in different tissues of human embryonic CNS. SS concentration was generally higher than that of MTL (P <0.01), of which SS content was the highest in the hypothalamus (P <0.01) No significant difference in the pituitary MTL occurred earlier than 16 weeks, SS later than 22 weeks, other parts of the SS appeared earlier than 16 weeks, MTL later than 22 weeks. With the development of embryos, the development of SS showed different trends: ① The hypothalamic SS concentration was positively correlated with gestational age (r = 0.7345, P <0.01). ② pituitary, medulla and spinal cord SS fluctuations in a certain level, no significant change. ③ Cerebral cortex and cerebellum SS first increased and then decreased, MTL development was consistent with gestational age increased. Suggesting that there are different rules for the occurrence, development and distribution of SS and MTL in human fetal CNS.