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目的分析围产期孕妇B族链球菌(GBS)产前筛查状况和耐药性,为临床预防感染与合理用药提供依据。方法回顾性分析2014年1月-2016年10月本院妇产科分离出GBS菌株围产期孕妇的临床资料。结果围产期孕妇GBS检出率在不同标本、不同季节、不同年龄间差异均无统计学意义(P>0.05),但居住农村和居住城市的孕妇间GBS检出率差异有统计学意义(P<0.05);药敏结果表明GBS对多数抗菌药物保持良好的抗菌活性,对喹诺酮类抗生素中度耐药,对红霉素、克林霉素高度耐药。结论围产期孕妇GBS的检出率与标本类型、标本采集季节、孕妇年龄均无显著相关性,应将农村居住孕妇作为GBS重点筛查对象;对于GBS携带者,应采取预防和治疗措施,青霉素G可作为围产期孕妇治疗GBS感染的首选药物。
Objective To analyze prenatal screening status and drug resistance of group B streptococci in pregnant women during perinatal period and provide evidences for clinical prevention of infection and rational drug use. Methods The clinical data of pregnant women with perinatal GBS strains isolated from obstetrics and gynecology in our hospital from January 2014 to October 2016 were retrospectively analyzed. Results The detection rate of GBS in pregnant women during perinatal period had no significant difference in different samples, different seasons and different ages (P> 0.05), but there was significant difference in the detection rate of GBS between pregnant women living in rural and living cities P <0.05). The drug susceptibility results showed that GBS maintained good antibacterial activity against most antibacterials, moderately resistant to quinolone antibiotics, and highly resistant to erythromycin and clindamycin. Conclusion The detection rate of GBS in perinatal pregnant women has no significant correlation with specimen type, specimen collection season and pregnant women’s age. Pregnant women living in rural areas should be the key screening target of GBS. For GBS carriers, prevention and treatment measures should be taken, Penicillin G can be used as the drug of choice for treating pregnant women with GBS during perinatal period.