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目的 :进一步探讨高危 HPV1 6、1 8与膀胱癌的病因学关系。方法 :运用改良的原位杂交技术对 5 2例福尔马林固定石蜡包埋膀胱乳头状移行细胞癌组织进行高危 HPV DNA定位检测。结果 :HPV DNA的阳性信号存在于肿瘤细胞核内 ,呈点状 ,也可为点片状 ,位于乳头癌全层。癌旁不典型增生上皮、癌旁正常的上皮组织及 Brunn氏巢可同时有高危 HPV的点片状表达。 5 2例膀胱乳头状移行细胞癌中高危型 HPV1 6、1 8DNA阳性 19例 ,阳性率为 36 .5 % ;其中 2例膀胱癌组织 HPV1 6 和 HPV1 8均阳性。结论 :膀胱乳头状移行细胞癌 HPV感染率较高 ,且病毒 DNA在癌旁正常及不典型增生组织中可有不同程度的表达 ,提示 HPV感染可能是膀胱癌的重要诱因之一 ;改良的原位杂交技术可用于对存档膀胱癌组织进行病毒感染的回顾性研究
Objective: To further explore the etiological relationship between high risk HPV16 and 18 and bladder cancer. Methods: The modified in situ hybridization technique was used to detect high-risk HPV DNA in 52 cases of formalin-fixed paraffin-embedded papillary transitional cell carcinoma of the bladder. Results: The positive signal of HPV DNA existed in the nucleus of the tumor cells, which was spot-like or flaky, which was located in the whole layer of papillary carcinoma. Adjacent to the atypical hyperplasia epithelial adjacent normal epithelial tissue and Brunn’s nest can have high-risk HPV dot-like expression. Among 52 cases of papillary transitional cell carcinoma of the bladder, high-risk HPV16,1,8 DNA was positive in 19 cases, the positive rate was 36.5%. Two of the two cases were positive for HPV16 and HPV18. Conclusions: The HPV infection rate of papillary transitional cell carcinoma of the bladder is high, and the expression of viral DNA in normal and atypical hyperplasia tissues may be different, suggesting that HPV infection may be one of the important causes of bladder cancer. A bit hybridization technique can be used to retrospectively study the virus infection of bladder cancer tissues