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在相对温和的反应条件以及PPh3 和KOtBu存在的情况下 ,Pd(OAc) 2 催化吡唑与 2 ,6 二溴吡啶 (摩尔比 1∶2 4 )的偶联反应主要生成单吡唑基取代的 2 溴 6 吡唑基吡啶 .在无Pd(OAc) 2 /PPh3 存在的情况下 ,则主要生成双吡唑基取代的 2 ,6 二吡唑基吡啶 .Pd(OAc) 2 与 2 溴 6 吡唑基吡啶反应生成的配合物中间体可能抑制了双吡唑基取代产物的生成 ,从而影响产物分布 .
Under relatively mild reaction conditions and the presence of PPh3 and KOtBu, Pd (OAc) 2 catalyzes the coupling reaction of pyrazole with 2,6-dibromopyridine (molar ratio 1: 24) to form mainly mono-pyrazolyl substituted In the absence of Pd (OAc) 2 / PPh3, the main pyrazolyl-substituted 2,6-di-pyrazolopyridine was obtained. Pd (OAc) The complex intermediates formed by the reaction of pyrazolopyridine may inhibit the formation of the double pyrazolyl substitution products and thus the product distribution.