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一般公认夜间胃酸分泌对H_2受体拮抗剂的治疗作用有重要影响。据观察,耐H_2受体拮抗剂的溃疡病人不能有效抑制胃酸,因此可在开始治疗时由胃酸监测识别。长期胃内pH记录与胃吸出物测定的pH相同,但长期胃内pH监测不干扰胃内容、病人的运动、营养、睡眠。本研究检验雷尼替丁(Ra)等对肝硬化病人和对照人群夜间胃内pH的影响。患者和方法:肝硬化病人27例,非肝硬化病人32例(对照)。诊断包括消化性溃疡病、糜烂性胃炎和球炎、返流性食管炎,均适应用H_2拮抗剂治疗。使用微型双极玻璃pH电极与关联电极相连。每6秒记录pH值,计算并记录8个连续记数的算术平
It is generally acknowledged that nighttime gastric acid secretion has an important influence on the therapeutic effect of H 2 receptor antagonists. It has been observed that patients with ulceration resistant to H 2 receptor antagonists do not effectively inhibit gastric acid and can thus be identified by gastric acid monitoring at the start of treatment. Long-term intragastric pH recordings have the same pH as gastric aspirates, but long-term gastric pH monitoring does not interfere with stomach contents, patient movement, nutrition, and sleep. This study examined the effects of ranitidine (Ra) on nocturnal gastric pH in patients with cirrhosis and control subjects. Patients and Methods: 27 patients with cirrhosis and 32 patients without cirrhosis (control). Diagnosis includes peptic ulcer disease, erosive gastritis and inflammation, reflux esophagitis, are suitable for treatment with H 2 antagonists. Use a miniature bipolar glass pH electrode connected to the associated electrode. Record pH every 6 seconds, calculate and record 8 arithmetic maths for consecutive counts