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为探讨乳腺非典型增生至癌变过程中血管生成的作用及其规律以及血管生成与非典型增生程度及癌变的关系，本研究应用免疫组化法，以ＦⅧ为标志物对８６例良、恶性乳腺病变组织中的血管内皮细胞进行组化染色。分别以微机图像分析系统和人工计数对微血管内皮细胞面积（ＭＥＡ）和微血管密度（ＭＶＤ）进行定量分析。结果发现，中重度非典型增生及癌变组织中的血管生成量ＭＥＡ和ＭＶＤ均明显高于正常乳腺、单纯上皮增生和轻度非典型增生（Ｐ＜０．０５）。结论：乳腺非典型增生过程中已有血管生成并随非典型增生程度的增加而增多；乳腺增生组织中的血管生成可反映乳腺癌前病变的恶性倾向
To investigate the role and regulation of angiogenesis during breast atypical hyperplasia to canceration and the relationship between angiogenesis and atypical hyperplasia and carcinogenesis, this study applied immunohistochemistry to identify 86 cases of benign and malignant mammary glands with FVIII as a marker. Vascular endothelial cells in the lesions were histochemically stained. Microvascular endothelial cell area (MEA) and microvessel density (MVD) were quantitatively analyzed by computer image analysis system and manual counting. The results showed that the angiogenesis MEA and MVD in moderately severe atypical hyperplasia and cancerous tissue were significantly higher than those in normal breast, simple epithelial hyperplasia and mild dysplasia (P<0.05). Conclusion: Angiogenesis has already occurred in the process of atypical hyperplasia of mammary gland and increased with the increase of atypical hyperplasia degree; angiogenesis in breast hyperplasia tissue may reflect the malignant tendency of precancerous lesion of breast