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目的:评价重组人血小板生长因子凝胶剂(rhPDGF-BB)对糖尿病大鼠创面修复的作用。方法:26只糖尿病大鼠在背部两侧各制备2个全层皮肤缺损创面,面积2.54cm~2,随机将创面分成五组,即 rhPDGF-BB 凝胶剂三个剂量治疗组(rhPDGF-BB 用量分别为14.0μg/cm~2、7.0μg/cm~2、3.50μg/cm~2)、凝胶剂基质对照组和空白对照组,观察伤后不同时间各组创面面积和伤腔容积的变化。结果:伤后14d rhPDGF-BB 中剂量治疗组创面
Objective: To evaluate the effect of recombinant human platelet growth factor gel (rhPDGF-BB) on wound healing in diabetic rats. Methods: Twenty-six diabetic rats were divided into three groups (rhPDGF-BB, rhPDGF-BB, and rhPDGF-BB) The dosage was 14.0μg / cm ~ 2, 7.0μg / cm ~ 2, 3.50μg / cm ~ 2 respectively), gelatin matrix control group and blank control group. The wound area and wound volume of each group were observed at different times after injury Variety. Results: The wounds were treated with rhPDGF-BB medium dose for 14 days after injury