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目的评估氯吡格雷联合氟伐他汀治疗脑梗死的临床疗效。方法选取2013年2月至2015年2月信阳职业技术学院附属医院收治的86例脑梗死患者作为研究对象,按随机数字表法分为两组:对照组43例采取常规方法治疗;观察组43例在常规治疗基础上采取氯吡格雷联合氟伐他汀治疗;对比两组临床疗效及治疗前后各项指标的变化情况。结果观察组治疗总有效率(95.35%)明显高于对照组(69.77%),两组比较差异有统计学意义(P<0.05)。治疗前两组总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及超敏C-反应蛋白比较差异未见统计学意义(P>0.05);治疗后,两组各项指标均有所改善,但观察组改善幅度明显大于对照组(P<0.05)。治疗前,两组日常生活能力、神经功能缺损评分比较差异未见统计学意义;治疗后,观察组上述两项指标改善效果均明显优于对照组(P<0.05)。结论对于脑梗死患者,采取氯吡格雷联合氟伐他汀治疗效果显著,值得在临床中采纳应用。
Objective To evaluate the clinical efficacy of clopidogrel combined with fluvastatin in the treatment of cerebral infarction. Methods Eighty-six patients with cerebral infarction admitted from Affiliated Hospital of Xinyang Polytechnic from February 2013 to February 2015 were selected and randomly divided into two groups according to random number table: control group, 43 cases were treated by conventional method; observation group 43 Cases of clopidogrel combined with fluvastatin on the basis of conventional treatment; comparison of the two groups of clinical efficacy and changes in the indicators before and after treatment. Results The total effective rate (95.35%) in the observation group was significantly higher than that in the control group (69.77%). There was significant difference between the two groups (P <0.05). Before treatment, there was no significant difference in total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and high-sensitivity C-reactive protein between the two groups (P> 0.05) All improved, but the observation group improved significantly more than the control group (P <0.05). Before treatment, there was no significant difference in daily living ability and neurological deficit scores between the two groups; after treatment, the improvement effect of the above two indexes in the observation group was significantly better than that in the control group (P <0.05). Conclusion For patients with cerebral infarction, clopidogrel combined with fluvastatin has a significant therapeutic effect and is worthy of clinical application.