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目的:通过对中西医结合治疗前后类风湿性关节炎(RA)活动性指标IL-1β、SIL-2R、IL-6以及血管内皮生 长因子VECF水平变化的检测,探讨RA与细胞因子的关系,探讨中西医结合治疗RA对细胞因子的调节作用。方法:将 RA患者分为两组,A组(中药、西药加针灸治疗组)、B组(西药治疗组),采用ELISA法分别检测两组患者治疗前后血清 IL-1β、SIL-2R、IL-6、VECF的水平,并设正常对照组观察。结果:A组、B组血清IL-1β、SIL-2R、IL-6与VECF水平均 明显高于正常对照组(P<0．05或P<0．01),与治疗前比较,A组各项指标均明显下降(P<0．05或P<0．01),B组IL-1β值 无明显变化,其它三项均下降(P<0．05),且A组的下降幅度明显高于B组。结论:细胞因子参与了类风湿性关节炎的发 生发展过程。中西医结合治疗对RA细胞因子具有调节作用。
Objective: To explore the relationship between RA and cytokines by detecting the levels of IL-1β, SIL-2R, IL-6 and Vascular endothelial growth factor VECF in rheumatoid arthritis (RA) before and after treatment with traditional Chinese and western medicine, To explore the regulation of cytokines by combining traditional Chinese and western medicine in the treatment of RA. Methods: The RA patients were divided into two groups: group A (Chinese medicine, western medicine plus acupuncture treatment group) and group B (western medicine treatment group). Serum levels of IL-1β, SIL-2R and IL were measured by ELISA before and after treatment -6, VECF levels, and set the normal control group. Results: The levels of IL-1β, SIL-2R, IL-6 and VECF in group A and group B were significantly higher than those in normal control group (P <0.05 or P <0.01) (P <0.05 or P <0.01). There was no significant change in IL-1β in group B, and the other three indexes decreased (P <0.05), and the decrease in group A was obvious Higher than the B group. Conclusion: Cytokines are involved in the development of rheumatoid arthritis. Integrative Medicine on the regulation of RA cytokines.