论文部分内容阅读
开心手术的细菌感染率高.作者研究了开心术病人体外循环期间头孢噻肟(CTX)的血浓度变化.在15例开心术病人(含先天性心脏病2例,后天性瓣膜疾病7例,缺血性心疾病6例.男12例,女3例,年龄38～67岁,体重50～70kg)的体外循环液体中加入CTX3g,于体外循环开始后5分、10分、30分、以后每隔30分采血.用生物法和HPLC法测定体外循环开始至210分钟的血中CTX及其代谢产物去乙酰CTX(DCTX)浓度变化.
Happy surgery has a high prevalence of bacterial infections. The authors studied changes in the blood concentration of cefotaxime (CTX) during cardiopulmonary bypass in a group of 15 patients with open heart surgery (including 2 cases of congenital heart disease, 7 cases of acquired valvular disease, Ischemic heart disease in 6 cases, 12 males and 3 females, aged 38 to 67 years old, body weight 50 ~ 70kg) of extracorporeal circulation fluid added CTX3g, 5 points after cardiopulmonary bypass, 10 points, 30 points, after Blood was collected every 30 minutes, and the changes of CTX and its metabolites deacetyl-CTX (DCTX) in blood were measured by biological and HPLC methods after the start of cardiopulmonary bypass.