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目的:比较新辅助化疗加放疗与单纯放疗治疗鼻咽癌的疗效。方法:214例患者随机分成2个组:1)观察组:新辅助化疗加常规放疗组;2)对照组:单纯常规放疗组。结果:放疗结束时观察组及对照组颈部淋巴结全消率94.6%及69.1%,前者优于后者;放疗结束后3个月观察组及对照组颈部淋巴结全消率95.8%及71.3%,前者仍优于后者并且能提高3a生存率。结论:新辅助化疗能提高对颈部淋巴结的局控制作用,改善近期疗效,而不增加放疗急性反应。
Objective: To compare neoadjuvant chemotherapy with radiotherapy and radiotherapy alone for the treatment of nasopharyngeal carcinoma. Methods: 214 patients were randomly divided into 2 groups: 1) observation group: neoadjuvant chemotherapy plus conventional radiotherapy; 2) control group: conventional radiotherapy alone group. Results: At the end of radiotherapy, the cervical lymph node dissection rate in observation group and control group were 94.6% and 69.1%, respectively. The former was better than the latter. After 3 months of radiotherapy, the complete elimination rate of cervical lymph nodes in observation group and control group was 95.8% and 71.3% , The former is still better than the latter and can improve 3a survival rate. Conclusion: Neoadjuvant chemotherapy can improve the control effect on the cervical lymph nodes and improve the short-term curative effect without increasing the acute radiation response.