11β羟基类固醇脱氢酶1(11βHSD1)在体内主要为还原酶,负责活性的糖皮质激素向其无活性前体的转换,调节局部糖皮质激素浓度,是糖皮质激素受体前调节,并决定糖皮质激素流向其受体而发挥作用。代谢综合征糖皮质激素敏感性增加,11βHSD1调节异常,可能是肥胖、糖耐量低减、高血压和心血管疾病等代谢综合征重要发病机制之一,选择性11βHSD1抑制剂有望成为其治疗靶点。 11β-hydroxysteroid dehydrogenase 1 (11βHSD1) is mainly a reductase in the body responsible for the conversion of active glucocorticoids to its inactive precursors and regulates the local glucocorticoid concentration, which is pre-glucocorticoid receptor-regulated and decided Glucocorticoids flow to their receptors and play a role. Metabolic syndrome glucocorticoid increased sensitivity, 11βHSD1 abnormal regulation, may be obesity, impaired glucose tolerance, hypertension and cardiovascular disease and other metabolic syndrome one of the important pathogenesis, selective 11βHSD1 inhibitor is expected to be its therapeutic target .