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目的 探讨帕米膦酸二钠 (博宁 )联合 1 5 3 Sm -EDTMP对恶性肿瘤多发骨转移的临床疗效。方法 32例恶性肿瘤多发骨转移患者随机分为 2组 ,每组 16例 ,分别接受 1 5 3Sm- EDTMP单独或与帕米膦酸二钠联合治疗。结果 联合组疼痛总缓解率 (CR+ PR)为 93.8% ,单用组为 6 2 .5% ,骨病灶控制总有效率 (CR+ PR)联合组 5 6 .3 % ,单用组为 18.8% ,联合组疗效优于单用组 (P<0 .0 5 ) ,两组均无明显的毒副作用。结论 帕米膦酸二钠联合 1 5 3 Sm - EDTMP是目前治疗晚期恶性肿瘤多发骨转移的优选方案
Objective To investigate the clinical efficacy of pamidronate (Bonin) combined with 153 Sm-EDTMP on multiple bone metastases in malignant tumors. Methods Thirty-two patients with multiple bone metastases of malignant tumors were randomly divided into two groups (16 in each group). The patients received 153 Sm-EDTMP alone or in combination with pamidronate disodium. Results The total pain relief rate (CR + PR) was 93.8% in the combination group, 62.5% in the single group, 56.3% in the combined group of CR + PR and 18.8% in the single group, The combination group was better than the single group (P <0. 05), both groups had no obvious side effects. Conclusion Pamidronate combined with 1 5 3 Sm - EDTMP is the best choice for the treatment of multiple bone metastases in advanced malignant tumors