乳腺癌和前列腺癌核素骨显像的火花现象已有过不少报道,发生率为5～10%。但该现象在其它肿瘤却很罕见。本文报告的2例小细胞肺癌的火花现象,既往未曾见于诸文献。病例1:59岁女性,咳嗽2月,X光胸片示右肺实质性病变,支气管镜取活检病理证实为小细胞肺癌。骨显像见颅骨有一放射性浓集灶并经X线证实。经过3个疗程的JM-8和VP-16化疗后再次骨显像,见腰椎出现两处新的浓集灶。按原方案完成了6个疗程的化疗后,上述浓集灶放射性普遍减弱。病例2:68岁男性,诉第10肋骨疼痛,CT扫描示右上肺叶2cm的病灶并肝转移,病理证实为小细胞肺癌。骨显像见多发性胸、腰椎病灶。经过3个 The spark phenomenon of radionuclide bone imaging in breast cancer and prostate cancer has been reported a lot, with an incidence of 5 to 10%. However, this phenomenon is rare in other tumors. The sparking phenomenon of 2 cases of small cell lung cancer reported in this paper has never been seen in the literature. Case 1:59-year-old woman, coughing in February, X-ray chest radiograph showing the right lung metastatic lesion, bronchoscopic biopsy pathology confirmed as small cell lung cancer. Bone scintigraphy showed a radioactively concentrated lesion in the skull and was confirmed by X-ray. After 3 cycles of JM-8 and VP-16 chemotherapy, bone imaging was performed again. Two new focal lesions were seen on the lumbar spine. After the completion of 6 cycles of chemotherapy according to the original protocol, the above-mentioned concentrated radioactivity was generally weakened. Case 2: A 68-year-old man complained of pain in the 10th rib. A CT scan showed 2cm lesions in the upper right lobe and hepatic metastases. Histopathology confirmed small cell lung cancer. Bone scans were seen in multiple thoracic and lumbar lesions. After 3