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目的探讨CEA、CA19-9、CA72-4联合检测对胃癌的诊断价值。方法采用电化学发光法分别检测60例健康体检者(对照组)、40例胃良性疾病(良性胃病组)及80例胃癌患者(胃癌组)血清中CEA、CA19-9、CA72-4,分析3种指标对胃癌的诊断价值。结果胃癌组血清CEA、CA19-9、CA72-4水平高与对照组及良性胃病组,差异有统计学意义(P<0.05),其血清CEA、CA19-9、CA72-4阳性检出率明显高于其他两组,差异有统计学意义(P<0.05);3种标志物联合检测其阳性检出率显著提高。结论血清CEA、CA19-9、CA72-4联检可提高胃癌的早期诊断率,降低误诊率,可作为胃癌诊断重要的检测手段。
Objective To investigate the diagnostic value of CEA, CA19-9 and CA72-4 in the diagnosis of gastric cancer. Methods The serum levels of CEA, CA19-9 and CA72-4 in 60 healthy subjects (control group), 40 gastric benign diseases (benign gastric diseases) and 80 gastric cancer patients (gastric cancer patients) were detected by electrochemiluminescence. Three kinds of indexes in the diagnosis of gastric cancer. Results The serum levels of CEA, CA19-9 and CA72-4 in gastric cancer group were significantly higher than those in control group and benign gastric cancer group (P <0.05), and the positive rates of CEA, CA19-9 and CA72-4 were significantly higher Higher than the other two groups, the difference was statistically significant (P <0.05); three markers combined detection of the positive detection rate was significantly increased. Conclusions The combination of serum CEA, CA19-9 and CA72-4 can improve the early diagnosis rate of gastric cancer and reduce the misdiagnosis rate, which can be used as an important detection method for gastric cancer diagnosis.