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目的:研究二陈汤的配伍机制;方法:采用混料均匀试验设计对二陈汤方中组成药味及药量进行加减拆方,并选择止咳、化痰两个药理指标,对所得11个处方分别进行药理实验,采用关联度分析和二次多项式逐步回归分析将所得药理数据和处方组成进行处理,用现代科学方法研究二陈汤的配伍机制;结果:证明了方中以半夏为君、以陈皮为臣、佐以茯苓、使以甘草的配伍关系,与该复方中药的传统诠释相一致;结论:本研究为探讨复方总要的配伍机制提供了有意义的尝试。
Objective: To study the compatibility mechanism of Erchen decoction. Methods: Using the uniform mixing test design, add and subtract prescriptions of Erchenngfang prescription and its prescriptions, and select two pharmacological indexes of cough-relieving and phlegm-resolving. Pharmacological experiments, the use of correlation analysis and stepwise polynomial regression analysis of the resulting pharmacological data and prescription composition for processing, using modern scientific methods to study the compatibility of Erchen decoction; Results: Chen, accompanied by Poria, compatibility of licorice with the traditional interpretation of traditional Chinese medicine consistent; Conclusion: This study provides a meaningful attempt to explore the general mechanism of compatibility.